KUSMS launched its own constituent MBBS program in August 2001. The school has infrastructure and physical facilities at two locations: Basic sciences building at a hilltop at Chaukot, Panauti Municipality-1 and the main teaching hospital is situated at Dhulikhel. Both locations are in close access to the Kathmandu University Complex. Basic Sciences department has 7 various departments with required number of laboratories, lecture halls (including PBL class rooms), audio visual facilities (media tech), and library with 24-hour internet facility.
The Degree awarded is Bachelor of Medicine and Bachelor of Surgery, MBBS. MBBS is an undergraduate course. It is a five-and-a-half-year long course which includes one year of internship.
The KUMS MBBS program has been divided into three parts: the first two years of study consists of basic medical sciences. These years also include an introduction to clinical sciences. Over the next two and half years, students learn the principles and skills of clinical medicine by rotating through various medical specialties. The final one year consists of internship.